Liquid chromatography–mass spectrometry (LC-MS) is an analytical chemistry technique which is widely used to analyze biochemical, organic, and inorganic compounds.
Synapse Laboratory uses Sciex API 3200 QTRAP LC-MS/MS system for newborn screening.
Liquid chromatography-tandem mass spectrometry (LC–MS/MS) has greatly increased the screening possibilities by monitoring levels of amino acids and acylcarnitines in newborns. LC–MS/MS can detect more than 40 inherited disorders with a single run from just a few drops of blood.
This technology has been successfully implemented on a large scale in many jurisdictions across the world including national NBS programs and private laboratories globally.
